Omega-3 May Combat Mouth Bacteria, Boost Oral Health...
Reports a New Study From
The University of Kentucky.
In addition to Omega 3 fish- derived nutritional lipids-oils
being beneficial for cardiovascular, bone & joint
health, now dental health
benefits of omega-3 fatty acids
may include anti-bacterial effects, extending the benefits beyond
inflammation, says a new study from the University of Kentucky.
Omega-3 fatty acids of marine and plant origin were found to have
strong anti-bacterial activity against a range of oral pathogens, according to findings published in Molecular Oral Microbiology.
EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid) and
ALA (alpha-linolenic acid), as well as their naturally-occurring fatty
acid ethyl esters could inhibit the growth of oral pathogens, including
Streptococcus mutans, Candida albicans, and Porphyromonas
ginigivalis at relatively low doses.
"To date, this is the first study to demonstrate the significant
antibacterial activity of omega-3 fatty acids and their esters against
oral pathogens," wrote the researchers from the Center for Oral
Health Research at U of K's College of Dentistry.
"Most Omega-3 studies on oral health have been focused on the
inflammation part; for some reason, the anti-bacterial activity has
not mentioned or ignored, including a recent Japanese study. The
anti-bacterial part of the omega-3 fatty acids could be very important.
Certainly, it could be a potential new use of omega-3 fatty acids as the nutraceuticals in the future," they added.
The new study looked at the effects of EPA, DHA, ALA and their
fatty acid ethyl esters, on a range of oral pathogens. All the omega-3
compounds studies were found to exhibit strong antibacterial activity.
The study, sponsored by the US National Institutes of Health, found
that the naturally-occurring compounds showed cent 50 per cent
inhibitory activity for concentrations ranging from 1 to 10 micrograms
per millilitre.
The research work in this area was ongoing and expanding. "Of
course, we plan to study and answer those questions about the
optimal dosages, pharmacokinetics, the delivery into the oral cavity,
and what kind of in vivo dosage/effect to expect, and so on," they
noted.
Source: Molecular Oral Microbiology
Volume 25 Issue 1, Pages 75 - 80
"A novel bioactivity of omega-3 polyunsaturated fatty acids
and their ester derivatives"
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